The motor neuron diseases (MNDs) are a group of progressive neurological disorders that destroy motor neurons, the cells that control skeletal muscle activity such as walking, breathing, speaking, and swallowing. (Definition by National Institute of Stroke and Neurological Disorders of india
This group includes diseases such as amyotrophic lateral sclerosis, progressive bulbar palsy, primary lateral sclerosis, progressive muscular atrophy, spinal muscular atrophy, Kennedy’s disease, and post-polio syndrome.
AMYOTROPIC LATERAL SCLEROSIS:
1.Amyotrophic lateral sclerosis is a subtype of Motor neuron disease .
* It is confined to the Corticospinal tracts and the Motor neurons of Anterior gray columns of spinal cord . It is a chronic progressive disease .
*Typically it occurs in late middle ages and is inevitable fatal in 2 to 6 years .
* The lower motor neuron signs of Muscular atrophy ,Paresis , and Fasciculation s are superimposed on the signs and symptoms of Upper Motor Neuron Disease with Paresis , Spasticity , and Babinski response .